Which statement correctly describes TH1 and TH2 helper T cell responses?

Which statement correctly describes TH1 and TH2 helper T cell responses?

• A. TH1 promotes humoral immunity and TH2 promotes cell-mediated immunity.
• B. TH1 promotes cell-mediated immunity (IFN-γ) and TH2 promotes humoral immunity (IL-4, IL-5, IL-13)
• C. Both TH1 and TH2 promote humoral immunity
• D. TH2 suppresses cell-mediated immunity

Answer: (B)

TH1 and TH2 are two CD4+ T helper cell subsets that coordinate different arms of the immune response. TH1 cells produce IFN-γ and promote cell-mediated immunity by activating macrophages and supporting cytotoxic T cell responses, which is crucial for defense against intracellular pathogens. TH2 cells produce IL-4, IL-5, and IL-13 and drive humoral immunity by helping B cells become antibody-secreting cells, including promoting class switching and IgE production in allergic responses. So the statement that TH1 is linked to cell-mediated immunity and TH2 to humoral immunity, with the associated cytokines, best describes their roles. The other options mix up these functions or oversimplify the interactions, since TH1 does not primarily promote humoral immunity, TH2 is not exclusively humoral without any cell-mediated effect, and while TH2 can influence TH1 activity, it does not simply suppress all cell-mediated immunity.

TH1 and TH2 are two CD4+ T helper cell subsets that coordinate different arms of the immune response. TH1 cells produce IFN-γ and promote cell-mediated immunity by activating macrophages and supporting cytotoxic T cell responses, which is crucial for defense against intracellular pathogens. TH2 cells produce IL-4, IL-5, and IL-13 and drive humoral immunity by helping B cells become antibody-secreting cells, including promoting class switching and IgE production in allergic responses. So the statement that TH1 is linked to cell-mediated immunity and TH2 to humoral immunity, with the associated cytokines, best describes their roles. The other options mix up these functions or oversimplify the interactions, since TH1 does not primarily promote humoral immunity, TH2 is not exclusively humoral without any cell-mediated effect, and while TH2 can influence TH1 activity, it does not simply suppress all cell-mediated immunity.